[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester

Base Information

• Chemical Name: [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester
• CAS No.: 195307-15-4
• Molecular Formula: C₃₃H₄₀N₃O₇P
• Molecular Weight: 621.67
• Mol file: 195307-15-4.mol

Synonyms:[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester

Chemical Property of [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester

There total 2 articles about [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid mono-(4-nitro-benzyl) ester (159830-24-7) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester (195307-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

2: CH₂Cl₂ / 3 h / Ambient temperature

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/ja962465o

Reference yield:

4-Aminobutanol (13325-10-5) + C29H30ClN2O6P (159830-25-8) → C33H40N3O7P + [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester (195307-15-4) + C62H69N5O13P2

Guidance literature:

In dichloromethane; for 3h; Yields of byproduct given; Ambient temperature;

DOI:10.1021/ja962465o

Reference yield:

acetic anhydride (108-24-7) + [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-amino-butyl ester 4-nitro-benzyl ester (195307-15-4) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-acetylamino-butyl ester 4-nitro-benzyl ester

Guidance literature:

In pyridine; for 3h; Ambient temperature;

DOI:10.1021/ja962465o

upstream raw materials:

4-Aminobutanol

C₂₉H₃₀ClN₂O₆P

[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid mono-(4-nitro-benzyl) ester