2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Base Information

Chemical Name:2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate
CAS No.:155351-75-0
Molecular Formula:C₁₃H₁₅F₃O₇S
Molecular Weight:372.319
Hs Code.:

Synonyms:2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

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Chemical Property of 2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

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Technology Process of 2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

There total 8 articles about 2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 155351-75-0
2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: 87.8 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

4: 99.5 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

5: 2.08 g / HCO₂NH₄, 10percent Pd/C / methanol / 0.17 h / Ambient temperature

6: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

7: 8 N aq. H₂SO₄ / tetrahydrofuran / 2 h / 50 °C

8: i-Pr₂NEt / CH₂Cl₂ / 36 h / Ambient temperature

With palladium on activated charcoal; n-butyllithium; sulfuric acid; ammonium formate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja00082a023

Reference yield:

: 155351-72-7
2-hydroxy-3-methoxy-5-<5-(methoxymethoxy)ethyl>benzaldehyde trimethylene acetal

: 155351-75-0
2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

2: 8 N aq. H₂SO₄ / tetrahydrofuran / 2 h / 50 °C

3: i-Pr₂NEt / CH₂Cl₂ / 36 h / Ambient temperature

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00082a023

Reference yield:

: 155351-68-1
2-O-benzyl-5-bromo-2-hydroxy-3-methoxybenzaldehyde

: 155351-75-0
2-formyl-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

3: 99.5 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

4: 2.08 g / HCO₂NH₄, 10percent Pd/C / methanol / 0.17 h / Ambient temperature

5: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

6: 8 N aq. H₂SO₄ / tetrahydrofuran / 2 h / 50 °C

7: i-Pr₂NEt / CH₂Cl₂ / 36 h / Ambient temperature

With palladium on activated charcoal; n-butyllithium; sulfuric acid; ammonium formate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ja00082a023