ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Base Information

Chemical Name:ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate
CAS No.:1354708-75-0
Molecular Formula:C₂₈H₂₃N₃O₆
Molecular Weight:497.507
Hs Code.:

Synonyms:ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Chemical Property of ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Technology Process of ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

There total 5 articles about ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1354709-85-5
methyl 2-amino-5-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]benzoate

: 459-73-4
GlyOEt*HCl

: 1354708-75-0
ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: bis(trichloromethyl) carbonate; methyl 2-amino-5-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]benzoate; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

GlyOEt*HCl; With triethylamine; In 1,4-dioxane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 4-oxo-2-phenyl-4H-3,1-benzoxazine-6-carboxylic acid

: 1354708-75-0
ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2.1: potassium hydroxide; water / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With water; caesium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1354709-84-4
2-amino-5-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]benzoic acid

: 1354708-75-0
ethyl {6-[(1-methoxy-2-phenylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;