phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Base Information

Chemical Name:phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate
CAS No.:1373396-62-3
Molecular Formula:C₂₆H₃₅N₅O₆Si
Molecular Weight:541.679
Hs Code.:

Synonyms:phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

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Chemical Property of phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

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Technology Process of phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

There total 3 articles about phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1885-14-9
phenyl chloroformate

: 139301-93-2
9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

: 1373396-62-3
phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol300777p

Reference yield:

: 362-75-4
2',3'-isopropylidene adenosine

: 1373396-62-3
phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: 1-methyl-1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; 1-methyl-1H-imidazole; In dichloromethane;
DOI:10.1021/ol300777p

Reference yield:

: 58-61-7
adenosine

: 1373396-62-3
phenyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: perchloric acid / water / 7 h / 0 - 20 °C

2: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3: 1-methyl-1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; 1-methyl-1H-imidazole; perchloric acid; In dichloromethane; water;
DOI:10.1021/ol300777p