4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal

Base Information

• Chemical Name: 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal
• CAS No.: 1055244-89-7
• Molecular Formula: C₁₂H₁₃BrN₂O₂
• Molecular Weight: 297.151
• Mol file: 1055244-89-7.mol

Synonyms:4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal

Chemical Property of 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal

Chemical Property:

Purity/Quality:

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Technology Process of 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal

There total 2 articles about 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-phenyl-1H-pyrazole-5-carboxaldehyde (132274-70-5) + trimethyl orthoformate (149-73-5) → 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal (1055244-89-7)

Guidance literature:

With pyridinium hydrobromide perbromide; toluene-4-sulfonic acid; In methanol; at 20 ℃; for 90h;

DOI:10.1016/j.bmc.2007.12.045

Reference yield: 87.0%

1-phenylpyrazole-5-carbaldehyde dimethyl acetal (1055246-96-2) → 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal (1055244-89-7)

Guidance literature:

With pyridinium hydrobromide perbromide; In methanol; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.bmc.2007.12.045

Reference yield: 32.0%

4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal (1055244-89-7) + N-ethoxycarbonyl-4-piperidone (29976-53-2) → ethyl 4-[5-(dimethoxymethyl)-1-phenylpyrazole-4-yl]-4-hydroxypiperidine-1-carboxylate (1021858-31-0)

Guidance literature:

4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 90h;

N-ethoxycarbonyl-4-piperidone; In tetrahydrofuran; at 20 ℃; for 24h; Further stages.;

DOI:10.1016/j.bmc.2007.12.045

upstream raw materials:

1-phenylpyrazole-5-carbaldehyde dimethyl acetal

1-phenyl-1H-pyrazole-5-carboxaldehyde

trimethyl orthoformate

Downstream raw materials:

ethyl 4-[5-(dimethoxymethyl)-1-phenylpyrazole-4-yl]-4-hydroxypiperidine-1-carboxylate

Refernces

• 1、 -. "Spiro-pyrano-pyrazole derivatives". Page/Page column 13; 19. . Retrieved 2008/12/04.