3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

Base Information

Chemical Name:3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one
CAS No.:1548889-68-4
Molecular Formula:C₂₃H₂₀FN₃O₅S
Molecular Weight:469.493
Hs Code.:

Synonyms:3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

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Chemical Property of 3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

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Technology Process of 3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

There total 8 articles about 3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 10438-96-7
N-methylsulfamoyl chloride

: 1548889-48-0
3-(2-amino-3-fluoropyridin-4-ylmethyl)-4-methyl-7-phenoxy-chromen-2-one

: 1548889-68-4
3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/ml400379x

Reference yield:

: 946127-54-4
(2-chloro-3-fluoro-pyridin-4-yl)methanol

: 1548889-68-4
3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4.17 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: lithium tert-butoxide; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 °C

4.2: 3.5 h / 0 - 50 °C

5.1: sulfuric acid / 4 h / 0 - 20 °C

6.1: pyridine / N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C

With pyridine; 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; sodium t-butanolate; lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ml400379x

Reference yield:

: 946127-55-5
4-(((tert-butyldimethylsilanyl)oxy)methyl)-2-chloro-3-fluoropyridine

: 1548889-68-4
3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4.17 h / 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: lithium tert-butoxide; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 °C

3.2: 3.5 h / 0 - 50 °C

4.1: sulfuric acid / 4 h / 0 - 20 °C

5.1: pyridine / N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; sodium t-butanolate; lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ml400379x