[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

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Chemical Name:[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate
CAS No.:1612897-08-1
Molecular Formula:C₃₂H₂₈Cl₂F₂N₂O₇
Molecular Weight:661.486
Hs Code.:

[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

Synonyms:[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

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Chemical Property of [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

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Technology Process of [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

There total 5 articles about [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1611456-48-4
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 3-formyl-2-hydroxy-benzoate

: 95-55-6
2-amino-phenol

: 1612897-08-1
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

Guidance literature:: [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 3-formyl-2-hydroxy-benzoate; 2-amino-phenol; With acetic acid; In methanol; at 20 ℃; for 16h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 3h;

Reference yield:

: 3775-05-1
methyl 3-formyl-2-hydroxybenzoate

: 1612897-08-1
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium hydroxide; methanol / tetrahydrofuran / 0.5 h / 0 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: trifluoroacetic acid / toluene / 0.83 h / 0 °C

5.1: acetic acid / methanol / 16 h / 20 °C

5.2: 3 h / 20 °C

With methanol; dmap; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1611456-46-2
methyl 2-(benzyloxy)-3-formylbenzoate

: 1612897-08-1
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[(2-hydroxyanilino)methyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; methanol / tetrahydrofuran / 0.5 h / 0 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: trifluoroacetic acid / toluene / 0.83 h / 0 °C

4.1: acetic acid / methanol / 16 h / 20 °C

4.2: 3 h / 20 °C

With methanol; dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;