5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole

Base Information

• Chemical Name: 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole
• CAS No.: 1265323-43-0
• Molecular Formula: C₂₂H₁₉N₃O₂
• Molecular Weight: 357.412
• Mol file: 1265323-43-0.mol

Synonyms:5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole

Chemical Property of 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole

There total 6 articles about 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-N'-hydroxy-4-vinylbenzimidamide (1265323-44-1,1062669-50-4) + 5-phenyl-4-propylisoxazole-3-carboxylic fluoride → 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole (1265323-43-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃;

Reference yield:

5-phenyl-4-propylisoxazole-3-carboxylic fluoride + 4-ethenyl-N-hydroxybenzene-1-carboximidamide → 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole (1265323-43-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 70 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00373

Reference yield:

1-phenyl-1-pentyne (4250-81-1) → 5-(5-phenyl-4-propylisoxazol-3-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole (1265323-43-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 18 h / 160 °C

2: sodium hydroxide / ethanol / 2 h / 75 °C

3: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C

With pyridine; trifluoro-[1,3,5]triazine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; acetonitrile;

upstream raw materials:

1-phenyl-1-pentyne

5-phenyl-4-propylisoxazole-3-carboxylic acid

(Z)-N'-hydroxy-4-vinylbenzimidamide

4-ethenylbenzonitrile

Downstream raw materials:

4-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperazine-2-carboxylic acid

2-(1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

3-(4-(oxiran-2-yl)phenyl)-5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazole

2-bromo-1-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol