Technology Process of 4-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperazine-2-carboxylic acid
There total 7 articles about 4-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperazine-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
piperazine-2-carboxylic acid;
With
tetra(n-butyl)ammonium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide;
at 20 ℃;
for 0.25h;
2-bromo-1-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol;
In
tetrahydrofuran; dimethyl sulfoxide;
at 80 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 18 h / 160 °C
2.1: sodium hydroxide / ethanol / 2 h / 75 °C
3.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 1 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
6.1: triethyl-bromo-silane / tetrahydrofuran / 1 h / -78 °C
7.1: tetra(n-butyl)ammonium hydroxide / dimethyl sulfoxide; tetrahydrofuran / 0.25 h / 20 °C
7.2: 1.5 h / 80 °C
With
pyridine; trifluoro-[1,3,5]triazine; triethyl-bromo-silane; tetra(n-butyl)ammonium hydroxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 1 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
4.1: triethyl-bromo-silane / tetrahydrofuran / 1 h / -78 °C
5.1: tetra(n-butyl)ammonium hydroxide / dimethyl sulfoxide; tetrahydrofuran / 0.25 h / 20 °C
5.2: 1.5 h / 80 °C
With
pyridine; trifluoro-[1,3,5]triazine; triethyl-bromo-silane; tetra(n-butyl)ammonium hydroxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;
