2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

Base Information

Chemical Name:2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine
CAS No.:874889-93-7
Molecular Formula:C₆₅H₉₄N₆O₁₄Si₃
Molecular Weight:1267.75
Hs Code.:

Synonyms:2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

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Chemical Property of 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

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Technology Process of 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

There total 1 articles about 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3'-O-(N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl)-2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)adenosine

: 874889-93-7
2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

Guidance literature:: With piperidine; In acetonitrile; at 20 ℃; for 2.5h;
DOI:10.1021/ol052484f

Reference yield: 99.0%

: 874944-64-6
6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

: 874889-93-7
2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

: C₁₀₂H₁₃₇N₉O₁₉SSi₃

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; at 20 ℃;
DOI:10.1021/ol052484f

Reference yield: 97.0%

: 874944-64-6
6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

: 874889-93-7
2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine

: 874889-95-9
2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

Guidance literature:: 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid; 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine; With pyridine; dicyclohexyl-carbodiimide; at 20 ℃;

With N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; In water; N,N-dimethyl-formamide; for 5h; Further stages.;
DOI:10.1021/jo702070m