2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

Base Information

• Chemical Name: 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine
• CAS No.: 874889-95-9
• Molecular Formula: C₈₄H₉₇N₉O₁₆S
• Molecular Weight: 1520.81
• Mol file: 874889-95-9.mol

Synonyms:2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

Chemical Property of 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

There total 1 articles about 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid (874944-64-6) + 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine (874889-93-7) → 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine (874889-95-9)

Guidance literature:

6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid; 2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine; With pyridine; dicyclohexyl-carbodiimide; at 20 ℃;

With N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; In water; N,N-dimethyl-formamide; for 5h; Further stages.;

DOI:10.1021/jo702070m

Reference yield:

2'-O-(bis(2-acetoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-4-N-(4,4'-dimethoxytrityl)cytidine 3'-(N,N-diisopropyl)methoxyphosphoramidite (874889-96-0) + 2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine (874889-95-9) → C142H183N12O33PSSi3

Guidance literature:

With 4 A molecular sieve; PhlmOTf; In dichloromethane; acetonitrile; for 1.7h;

DOI:10.1021/ol052484f

upstream raw materials:

6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

2'-O-(bis(2-methoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-6-N-(4,4'-dimethoxytrityl)-3'-O-(L-phenylalanyl)adenosine