7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Base Information

Chemical Name:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide
CAS No.:76488-22-7
Molecular Formula:C₁₆H₁₄ClFN₄O
Molecular Weight:332.765
Hs Code.:

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

There total 3 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 76488-09-0
7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

: 76488-22-7
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; Ambient temperature; overnight;
DOI:10.1002/jhet.5570200313

Reference yield:

: 76488-35-2
7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine

: 76488-22-7
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / NH₃ / ethanol / Ambient temperature; overnight

2: 65 percent / NaBH₄ / ethanol; tetrahydrofuran / Ambient temperature; overnight

With sodium tetrahydroborate; ammonia; In tetrahydrofuran; ethanol;
DOI:10.1002/jhet.5570200313

Reference yield:

: 59467-63-9
7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine

: 76488-22-7
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / NaNO₂ / acetic acid / 0.25 h / Ambient temperature

2: 69 percent / NH₃ / ethanol / Ambient temperature; overnight

3: 65 percent / NaBH₄ / ethanol; tetrahydrofuran / Ambient temperature; overnight

With sodium tetrahydroborate; ammonia; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1002/jhet.5570200313