(R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

Base Information

Chemical Name:(R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate
CAS No.:1403619-12-4
Molecular Formula:C₁₈H₁₆N₂O₇
Molecular Weight:372.334
Hs Code.:

Synonyms:(R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

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Chemical Property of (R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

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Technology Process of (R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

There total 2 articles about (R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1403619-07-7
2,6-dimethyl-4-nitrophenyl acrylate

: 555-16-8
4-nitrobenzaldehdye

: 1403619-12-4
(R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

Guidance literature:: 4-nitrobenzaldehdye; With 4-[(5S)-3-ethyl-4-oxa-1-azatricyclo[4.4.0.03,8]decan-5-yl]quinolin-6-yl (2,2,2-trichloroacetyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Molecular sieve;

2,6-dimethyl-4-nitrophenyl acrylate; In N,N-dimethyl-formamide; at -35 ℃; for 18h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/ejoc.201200405

Reference yield:

: 2423-71-4
2,6-dimethyl-4-nitro phenol

: 1403619-12-4
(R)-2,6-dimethyl-4-nitrophenyl 2-[hydroxy(4-nitrophenyl)methyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: 4-[(5S)-3-ethyl-4-oxa-1-azatricyclo[4.4.0.03,8]decan-5-yl]quinolin-6-yl (2,2,2-trichloroacetyl)carbamate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Molecular sieve

2.2: 18 h / -35 °C

With dmap; 4-[(5S)-3-ethyl-4-oxa-1-azatricyclo[4.4.0.03,8]decan-5-yl]quinolin-6-yl (2,2,2-trichloroacetyl)carbamate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2.1: Morita-Baylis-Hillman reaction / 2.2: Morita-Baylis-Hillman reaction;
DOI:10.1002/ejoc.201200405