(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

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Chemical Name:(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate
CAS No.:1048965-87-2
Molecular Formula:C₂₆H₂₃ClFN₅O₆S
Molecular Weight:588.016
Hs Code.:

Synonyms:(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

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Chemical Property of (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

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Technology Process of (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

There total 7 articles about (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1257424-16-0
C₂₇H₂₀ClFN₄O₇S₃

: 133409-72-0
methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

: 1048965-87-2
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3390/molecules15129024

Reference yield:

: 120974-97-2
methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate

: 1048965-87-2
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile)

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.3390/molecules15129024

Reference yield:

: 112006-20-9
C₉H₈ClFN₂O₂

: 1048965-87-2
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(phenylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-2-(methoxyimino)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / Reflux

2: sulfuric acid; nitric acid / 0 - 20 °C

3: iron; ammonium chloride / ethanol; water / Reflux

4: triethylamine / dichloromethane / 0 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; diphenyl phosphoryl azide; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Schmidt reaction;
DOI:10.3390/molecules15129024