3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one

Base Information

• Chemical Name: 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one
• CAS No.: 413591-36-3
• Molecular Formula: C₂₃H₁₈N₂O₂
• Molecular Weight: 354.408
• Mol file: 413591-36-3.mol

Synonyms:3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one

Chemical Property of 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one

Chemical Property:

Purity/Quality:

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Technology Process of 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one

There total 1 articles about 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-biphenyl-carboxylic acid chloride (14002-51-8) + edaravone (89-25-8) → 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one (413591-36-3)

Guidance literature:

edaravone; With calcium hydroxide; In 1,4-dioxane; for 0.5h; Reflux;

4-biphenyl-carboxylic acid chloride; In 1,4-dioxane; for 24h; Reflux;

DOI:10.1021/jm500458c

Reference yield: 88.0%

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 (52462-29-0) + 3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one (413591-36-3) → [(p-cymene)Ru(4-(biphenyl-4-carbonyl)-3-methyl-1-phenyl-5-pyrazolonate)Cl]

Guidance literature:

3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one; With potassium hydroxide; In methanol; at 20 ℃; for 1h;

[ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In methanol; for 24h; Reflux;

DOI:10.1021/jm500458c

Reference yield: 88.0%

3-methyl-1-phenyl-4-[(4-phenylphenyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-one (413591-36-3) + N,N-dimethylethylenediamine (108-00-9) → C27H28N4O (1419286-10-4)

Guidance literature:

In ethanol; for 24h; Reflux; Inert atmosphere;

DOI:10.1039/c2dt32487c

upstream raw materials:

4-biphenyl-carboxylic acid chloride

edaravone

Downstream raw materials:

C₂₇H₂₈N₄O