(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

Base Information

Chemical Name:(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone
CAS No.:894790-87-5
Molecular Formula:C₂₂H₁₉F₇O₂
Molecular Weight:448.38
Hs Code.:

Synonyms:(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

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Chemical Property of (3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

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Technology Process of (3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

There total 10 articles about (3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 894790-85-3
(7R,8S)-8-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-7-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]decane

: 894790-87-5
(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 20 ℃;
DOI:10.1016/j.tetlet.2005.12.067

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 894790-87-5
(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd₂(dba)3; Xantphos; NaOtBu / tetrahydrofuran / 0.33 h

1.2: 70 percent / tetrahydrofuran / 10 h / 80 °C

2.1: (R)-2-methyl-CBS-oxazaborolidine; BH₃*DMS / toluene / 4.5 h / -40 - -6 °C

3.1: 50 percent / tetrafluoroboric acid / 1,2-dichloro-ethane; hexane / -16 °C

4.1: 72 percent / TFA / H₂O; CH₂Cl₂ / 20 °C

With tetrafluoroboric acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; dimethylsulfide borane complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; hexane; dichloromethane; water; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.tetlet.2005.12.067

Reference yield:

: (3R,4S)-3-(4-Fluoro-phenyl)-4-hydroxy-cyclohexanone

: 894790-87-5
(3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / CSA / toluene / Heating

2: 50 percent / tetrafluoroboric acid / 1,2-dichloro-ethane; hexane / -16 °C

3: 72 percent / TFA / H₂O; CH₂Cl₂ / 20 °C

With tetrafluoroboric acid; camphor-10-sulfonic acid; trifluoroacetic acid; In hexane; dichloromethane; water; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.tetlet.2005.12.067