1,4-Dioxaspiro[4.5]decan-8-one, 7-(4-fluorophenyl)-

Base Information

Chemical Name:1,4-Dioxaspiro[4.5]decan-8-one, 7-(4-fluorophenyl)-
CAS No.:877814-52-3
Molecular Formula:C14H15FO3
Molecular Weight:250.27
Hs Code.:

Synonyms:

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Chemical Property of 1,4-Dioxaspiro[4.5]decan-8-one, 7-(4-fluorophenyl)-

Chemical Property:

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Safty Information:

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Technology Process of 1,4-Dioxaspiro[4.5]decan-8-one, 7-(4-fluorophenyl)-

There total 1 articles about 1,4-Dioxaspiro[4.5]decan-8-one, 7-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 460-00-4
1-Bromo-4-fluorobenzene

: 877814-52-3
7-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-one

Guidance literature:: cyclohexanedione monoethylene ketal; With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; for 0.333333h;

1-Bromo-4-fluorobenzene; In tetrahydrofuran; at 80 ℃; for 10h;
DOI:10.1016/j.tetlet.2005.12.067

Reference yield:

: 877814-52-3
7-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-one

: 993-07-7
trimethylsilan

: 1235493-15-8
(9-(4-fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-en-8-yloxy)trimethylsilane

Guidance literature:: 7-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

trimethylsilan; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 877814-52-3
7-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-one

: (1R,3R,4S)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: (R)-2-methyl-CBS-oxazaborolidine; BH₃*DMS / toluene / 4.5 h / -40 - -6 °C

2: 50 percent / tetrafluoroboric acid / 1,2-dichloro-ethane; hexane / -16 °C

3: 72 percent / TFA / H₂O; CH₂Cl₂ / 20 °C

4: 80 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

5: 94 percent / H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With tetrafluoroboric acid; dimethylsulfide borane complex; hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; palladium on activated charcoal; In hexane; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.tetlet.2005.12.067