ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate

Base Information

• Chemical Name: ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate
• CAS No.: 444573-49-3
• Molecular Formula: C₃₇H₅₁O₅P
• Molecular Weight: 606.783
• Mol file: 444573-49-3.mol

Synonyms:ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate

Chemical Property of ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate

There total 3 articles about ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

heptyl(diphenyl)phosphineoxide (79422-30-3) + ethyl 6-(7-formylheptyl)-2-methoxybenzoate (114802-11-8) → ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate (444573-49-3)

Guidance literature:

heptyl(diphenyl)phosphineoxide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h;

ethyl 6-(7-formylheptyl)-2-methoxybenzoate; In tetrahydrofuran; at -78 - 25 ℃; for 2h;

DOI:10.1081/SCC-120002710

Reference yield:

1-Bromoheptane (629-04-9) → ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate (444573-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 72 h / Heating

1.2: 94 percent / aq. NaOH / 0.5 h / Heating

2.1: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

2.2: 76 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1081/SCC-120002710

Reference yield:

triphenylphosphine (603-35-0) → ethyl 6-(8'-hydroxy-9'diphenylphosphinopentadecyl)-2-methoxybenzoate (444573-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 72 h / Heating

1.2: 94 percent / aq. NaOH / 0.5 h / Heating

2.1: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

2.2: 76 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1081/SCC-120002710

upstream raw materials:

heptyl(diphenyl)phosphineoxide

ethyl 6-(7-formylheptyl)-2-methoxybenzoate

1-Bromoheptane

triphenylphosphine

Downstream raw materials:

(E) ethyl 2-methoxy-6-(8'-pentadecenyl)benzoate

(E) 2-methoxy-6-(8'-pentadecenyl)benzoic acid

(E) 6-(8'-pentadecenyl)salicylic acid

ethyl 6-(8'-oxo-9'diphenylphosphinopentadecyl)-2-methoxybenzoate