79422-30-3Relevant academic research and scientific papers
Reaction of (2-methoxyprop-2-yl)diphenylphosphine oxide with alkyl bromides
Morgalyuk, Vasilii P.,Strelkova, Tatyana V.,Kagramanov, Nikolai D.,Artem'ev, Alexander V.,Brel, Valery K.
, p. 290 - 291 (2018/06/01)
Treatment of (2-methoxyprop-2-yl)diphenylphosphine oxide with alkyl bromides affords alkyl(diphenyl)phosphine oxides in good yields.
Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides
Chen, Long,Zhu, Yueyue,Chen, Tieqiao,Liu, Long,Zhang, Ji-Shu,Han, Li-Biao
supporting information, p. 5090 - 5093 (2018/07/29)
A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.
Alcohol-based Michaelis-Arbuzov reaction: An efficient and environmentally-benign method for C-P(O) bond formation
Ma, Xiantao,Xu, Qing,Li, Huan,Su, Chenliang,Yu, Lei,Zhang, Xu,Cao, Hongen,Han, Li-Biao
supporting information, p. 3408 - 3413 (2018/08/06)
The famous Michaelis-Arbuzov reaction is extensively used both in the laboratory and industry to manufacture tons of widely-used organophosphoryl compounds every year. However, this method and the modified Michaelis-Arbuzov reactions developed recently still have some limitations. We now report a new alcohol-version of the Michaelis-Arbuzov reaction that can provide an efficient and environmentally-benign method to address the problems of the known Michaelis-Arbuzov reactions. That is, a wide range of alcohols can readily react with phosphites, phosphonites, and phosphinites to give all the three kinds of phosphoryl compounds (phosphonates, phosphinates, and phosphine oxides) using an n-Bu4NI-catalyzed efficient C-P(O) bond formation reaction. This general method can also be easily scaled up and used for further synthetic transformations in one pot.
Synthesis of an unnatural anacardic acid analogue
Green, Ivan R.,Tocoli, Felismino E.
, p. 947 - 957 (2007/10/03)
The unnatural E isomer of anacardic acid 7 has been synthesized employing the following key steps: Swern oxidation of a diastereoisomeric mixture of β-hydroxyphosphine oxides 13a/b to the corresponding ketone 14 followed by stereo-specific reduction to th
