79422-30-3Relevant academic research and scientific papers
Reaction of (2-methoxyprop-2-yl)diphenylphosphine oxide with alkyl bromides
Morgalyuk, Vasilii P.,Strelkova, Tatyana V.,Kagramanov, Nikolai D.,Artem'ev, Alexander V.,Brel, Valery K.
, p. 290 - 291 (2018/06/01)
Treatment of (2-methoxyprop-2-yl)diphenylphosphine oxide with alkyl bromides affords alkyl(diphenyl)phosphine oxides in good yields.
Alcohol-based Michaelis-Arbuzov reaction: An efficient and environmentally-benign method for C-P(O) bond formation
Ma, Xiantao,Xu, Qing,Li, Huan,Su, Chenliang,Yu, Lei,Zhang, Xu,Cao, Hongen,Han, Li-Biao
supporting information, p. 3408 - 3413 (2018/08/06)
The famous Michaelis-Arbuzov reaction is extensively used both in the laboratory and industry to manufacture tons of widely-used organophosphoryl compounds every year. However, this method and the modified Michaelis-Arbuzov reactions developed recently still have some limitations. We now report a new alcohol-version of the Michaelis-Arbuzov reaction that can provide an efficient and environmentally-benign method to address the problems of the known Michaelis-Arbuzov reactions. That is, a wide range of alcohols can readily react with phosphites, phosphonites, and phosphinites to give all the three kinds of phosphoryl compounds (phosphonates, phosphinates, and phosphine oxides) using an n-Bu4NI-catalyzed efficient C-P(O) bond formation reaction. This general method can also be easily scaled up and used for further synthetic transformations in one pot.
Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides
Chen, Long,Zhu, Yueyue,Chen, Tieqiao,Liu, Long,Zhang, Ji-Shu,Han, Li-Biao
supporting information, p. 5090 - 5093 (2018/07/29)
A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.
Synthesis of an unnatural anacardic acid analogue
Green, Ivan R.,Tocoli, Felismino E.
, p. 947 - 957 (2007/10/03)
The unnatural E isomer of anacardic acid 7 has been synthesized employing the following key steps: Swern oxidation of a diastereoisomeric mixture of β-hydroxyphosphine oxides 13a/b to the corresponding ketone 14 followed by stereo-specific reduction to th
