N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide

Base Information

• Chemical Name: N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide
• CAS No.: 15998-56-8
• Molecular Formula: C₁₅H₂₁N₃O₄S
• Molecular Weight: 339.415
• Mol file: 15998-56-8.mol

Synonyms:N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide

Chemical Property of N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide

There total 5 articles about N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

Cbz-Met-OH (1152-62-1) + glycinamide hydrochloride (1668-10-6) → N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide (15998-56-8)

Guidance literature:

With phosphate buffer; pronase EC 3.4.24.4; triethylamine; In ethyl acetate; at 30 ℃; for 24h;

Reference yield:

benzyl (S)-(1-hydrazinyl-4-(methylthio)-1-oxobutan-2-yl)carbamate (3561-51-1) → N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide (15998-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl; acetic acid; NaNO₂ / 0 °C / Umsetzung des gebildeten Azids mit Glycin-aethylester in Aether

2: methanol; NH₃

With hydrogenchloride; methanol; ammonia; acetic acid; sodium nitrite;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-(N-benzyloxycarbonyl-L-methionyl)-glycine amide (15998-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: water containing ethyl acetate / Umsetzung des Reaktionsprodukts mit Hydrazin-hydrat in Aethanol

2: aqueous HCl; acetic acid; NaNO₂ / 0 °C / Umsetzung des gebildeten Azids mit Glycin-aethylester in Aether

3: methanol; NH₃

With hydrogenchloride; methanol; ammonia; acetic acid; ethyl acetate; sodium nitrite;

upstream raw materials:

N-benzyloxycarbonyl-L-methionylglycine ethyl ester

methyl (S)-2-(benzyloxycarbonylamino)-4-methylmercaptobutanoate

H-Gly-NH₂

Cbz-Met-OH