N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide
CAS No.:1456620-21-5
Molecular Formula:C₂₇H₂₃F₄N₅O₂
Molecular Weight:525.506
Hs Code.:

Synonyms:N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

There total 11 articles about N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1456620-22-6
3-[4-(cyclopropylcarbamoyl)-3-methylphenyl]-N-methoxy-N-methyl-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazine-6-carboxamide

: 17318-03-5
bromo(3-fluorophenyl)magnesium

: 1456620-21-5
N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: In tetrahydrofuran; at -20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1365243-96-4
6-bromo-3-iodo-N-(3,3,3-trifluoropropyl)imidazo[1,2-b]pyridazin-8-amine

: 1456620-21-5
N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 12 h / 45 °C / Inert atmosphere

2: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 24 h / 100 °C / 6750.68 - 9000.9 Torr / Inert atmosphere

3: TurboGrignard / tetrahydrofuran / 3 h / -20 °C / Inert atmosphere

4: tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; In tetrahydrofuran; water;

Reference yield:

: 1351374-48-5
N-cyclopropyl-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1456620-21-5
N-cyclopropyl-4-{6-(3-fluorobenzoyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 12 h / 45 °C / Inert atmosphere

2: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 24 h / 100 °C / 6750.68 - 9000.9 Torr / Inert atmosphere

3: TurboGrignard / tetrahydrofuran / 3 h / -20 °C / Inert atmosphere

4: tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; In tetrahydrofuran; water;