N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 1432436-20-8
• Molecular Formula: C₁₅H₁₈FN₃OS
• Molecular Weight: 307.392
• Mol file: 1432436-20-8.mol

Synonyms:N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide

Chemical Property of N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide

There total 2 articles about N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde (1183623-74-6) + S-tert-butylsulfinimide (146374-27-8) → N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide (1432436-20-8)

Guidance literature:

With titanium(IV) isopropylate; In dichloromethane; at 20 ℃; for 10h; Cooling with ice;

Reference yield:

4-bromo-2-fluorobenzyl alcohol (188582-62-9) → N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide (1432436-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Sealed tube; Microwave irradiation

2: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

3: titanium(IV) isopropylate / dichloromethane / 10 h / 20 °C / Cooling with ice

With titanium(IV) isopropylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;

Reference yield:

N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide (1432436-20-8) + methylmagnesium bromide (75-16-1) → N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (1432436-23-1)

Guidance literature:

In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; for 10h; Inert atmosphere;

upstream raw materials:

4-bromo-2-fluorobenzyl alcohol

2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde

S-tert-butylsulfinimide

Downstream raw materials:

N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide