N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide
CAS No.:1432436-23-1
Molecular Formula:C₁₆H₂₂FN₃OS
Molecular Weight:323.435
Hs Code.:

Synonyms:N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

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Chemical Property of N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

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Technology Process of N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

There total 4 articles about N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432436-20-8
N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide

: 75-16-1
methylmagnesium bromide

: 1432436-23-1
N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; for 10h; Inert atmosphere;

Reference yield:

: 188582-62-9
4-bromo-2-fluorobenzyl alcohol

: 1432436-23-1
N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Sealed tube; Microwave irradiation

2: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

3: titanium(IV) isopropylate / dichloromethane / 10 h / 20 °C / Cooling with ice

4: tetrahydrofuran; dichloromethane / 10 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1418201-67-8
4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole

: 1432436-23-1
N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

2: titanium(IV) isopropylate / dichloromethane / 10 h / 20 °C / Cooling with ice

3: tetrahydrofuran; dichloromethane / 10 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;