Technology Process of benzylsulfonyl-(D)-Ser(tBu)-Gly-4-aminobenzylamide
There total 7 articles about benzylsulfonyl-(D)-Ser(tBu)-Gly-4-aminobenzylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 8h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide); dichloromethane / 2.5 h / 20 °C
3: piperazine-1-yl methyl resin; N-ethyl-N,N-diisopropylamine / dichloromethane / 289 h
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 5.5 h / 20 °C
5: hydrogen / palladium on activated charcoal / methanol / 8 h
With
hydrogenchloride; piperazine-1-yl methyl resin; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide); dichloromethane / 2.5 h / 20 °C
4: piperazine-1-yl methyl resin; N-ethyl-N,N-diisopropylamine / dichloromethane / 289 h
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 5.5 h / 20 °C
6: hydrogen / palladium on activated charcoal / methanol / 8 h
With
hydrogenchloride; piperazine-1-yl methyl resin; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); dichloromethane;
