2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

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Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid
CAS No.:1402143-74-1
Molecular Formula:C₂₅H₂₆O₄S
Molecular Weight:422.545
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

There total 11 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402143-80-9
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate

: 1402143-74-1
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate; In ethanol; for 4h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1402143-74-1
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine; sulfur / ethanol / 60 °C

2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 1 h / 60 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C

4.1: water / ethanol / 0.5 h / Reflux

4.2: pH 3

5.1: thionyl chloride; sodium tetrahydroborate / dimethyoxyethane / 1 h / 10 - 20 °C / Inert atmosphere; Reflux

6.1: manganese(IV) oxide / dichloromethane / 2.67 h / 20 °C

7.1: zinc(II) iodide / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

8.1: water / 0.17 h / 0 - 20 °C

9.1: perchloric acid / 0.5 h / 0 °C

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4.08 h / 95 °C / Inert atmosphere

11.1: ethanol / 4 h / Reflux

With manganese(IV) oxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; tert.-butylnitrite; perchloric acid; water; sodium carbonate; sulfur; triethylamine; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dimethyoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 38695-72-6
methyl 5-phenylthiophene-3-carboxylate

: 1402143-74-1
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C

2.1: water / ethanol / 0.5 h / Reflux

2.2: pH 3

3.1: thionyl chloride; sodium tetrahydroborate / dimethyoxyethane / 1 h / 10 - 20 °C / Inert atmosphere; Reflux

4.1: manganese(IV) oxide / dichloromethane / 2.67 h / 20 °C

5.1: zinc(II) iodide / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

6.1: water / 0.17 h / 0 - 20 °C

7.1: perchloric acid / 0.5 h / 0 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4.08 h / 95 °C / Inert atmosphere

9.1: ethanol / 4 h / Reflux

With manganese(IV) oxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; perchloric acid; water; sodium carbonate; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dimethyoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;