Technology Process of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate
There total 10 articles about methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; toluene;
at 95 ℃;
for 4.08333h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: triethylamine; sulfur / ethanol / 60 °C
2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 1 h / 60 °C
3.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C
4.1: water / ethanol / 0.5 h / Reflux
4.2: pH 3
5.1: thionyl chloride; sodium tetrahydroborate / dimethyoxyethane / 1 h / 10 - 20 °C / Inert atmosphere; Reflux
6.1: manganese(IV) oxide / dichloromethane / 2.67 h / 20 °C
7.1: zinc(II) iodide / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere
8.1: water / 0.17 h / 0 - 20 °C
9.1: perchloric acid / 0.5 h / 0 °C
10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol; water / 4.08 h / 95 °C / Inert atmosphere
With
manganese(IV) oxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; tert.-butylnitrite; perchloric acid; water; sodium carbonate; sulfur; triethylamine; zinc(II) iodide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dimethyoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C
2.1: water / ethanol / 0.5 h / Reflux
2.2: pH 3
3.1: thionyl chloride; sodium tetrahydroborate / dimethyoxyethane / 1 h / 10 - 20 °C / Inert atmosphere; Reflux
4.1: manganese(IV) oxide / dichloromethane / 2.67 h / 20 °C
5.1: zinc(II) iodide / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere
6.1: water / 0.17 h / 0 - 20 °C
7.1: perchloric acid / 0.5 h / 0 °C
8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol; water / 4.08 h / 95 °C / Inert atmosphere
With
manganese(IV) oxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; perchloric acid; water; sodium carbonate; zinc(II) iodide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dimethyoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;