38695-72-6

Upstream product

• 1371636-89-3 methyl trans-2-(phenoxymethylene)-4-phenylbut-3-ynoate 
• 61325-02-8 2-amino-5-phenylthiophene-3-carboxylic acid methyl ester 
• 88770-19-8 5-bromothiophene-3-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 

Downstream Products

• 99578-58-2 5-phenyl-thiophene-3-carboxylic acid 
• 79757-73-6 (5-phenylthiophen-3-yl)methanol 
• 1187467-82-8 2-bromo-5-phenyl-thiophene-3-carboxylic acid 
• 1402143-79-6 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-(tert-butoxy)acetate 
• 1402143-80-9 methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate 
• 1402143-74-1 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid 
• 1402143-75-2 methyl 2-bromo-5-phenylthiophene-3-carboxylate 
• 1402143-76-3 (2-bromo-5-phenylthiophen-3-yl)methanol 
• 116016-65-0 2-bromo-5-phenylthiophene-3-carbaldehyde 
• 1402143-77-4 2-(2-bromo-5-phenylthiophen-3-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 1402143-78-5 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-hydroxyacetate 

Relevant academic research and scientific papers

Thiophene derivative and synthetic method thereof

The invention discloses a thiophene derivative of a formula (I) and a synthetic method thereof. Thiobenzamide and an eneyne ester compound are used as raw materials, in the effects of base catalysis, the thiophene derivative of the formula (I) is synthesized. The preparation method has the advantages of mild reaction condition without metal catalysis, cheap catalyst, good yield, good selectivity, environmental friendliness, and the like. Halogen and ester group are contained in the thiophene derivative of the formula (I), in order to facilitate further conversion and synthesize other substances.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.