(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate
CAS No.:1339925-36-8
Molecular Formula:C₂₄H₂₃N₇O₅S₂
Molecular Weight:553.623
Hs Code.:

Synonyms:(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

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Chemical Property of (E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

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Technology Process of (E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

There total 8 articles about (E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.3%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1339925-35-7
(E)-methyl 3-(4-(N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

: 1339925-36-8
(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; at 130 ℃; for 5h; Inert atmosphere;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1339925-36-8
(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; acetic acid / 70 °C

2.1: trichlorophosphate / 12 h / Reflux

3.1: methanol / 2 h / 20 °C

4.1: sulfuric acid; nitric acid / 27.5 h / 0 °C

5.1: hydrogenchloride; tin / methanol; water / 50 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 20 °C

6.2: 3 h / Reflux

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; dimethyl sulfoxide / 5 h / 130 °C / Inert atmosphere

With hydrogenchloride; tin; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; bromine; nitric acid; sodium hydride; sodium hydrogencarbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; mineral oil;

Reference yield:

: 41102-02-7
7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

: 1339925-36-8
(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 12 h / Reflux

2.1: methanol / 2 h / 20 °C

3.1: sulfuric acid; nitric acid / 27.5 h / 0 °C

4.1: hydrogenchloride; tin / methanol; water / 50 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 20 °C

5.2: 3 h / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; dimethyl sulfoxide / 5 h / 130 °C / Inert atmosphere

With hydrogenchloride; tin; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; mineral oil;