(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

Base Information

Chemical Name:(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide
CAS No.:1339925-28-8
Molecular Formula:C₂₃H₂₂N₈O₅S₂
Molecular Weight:554.61
Hs Code.:

Synonyms:(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

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Chemical Property of (E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

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Technology Process of (E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

There total 9 articles about (E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1339925-36-8
(E)-methyl 3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

: 1339925-28-8
(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: With hydroxylamine; In methanol; dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1339925-35-7
(E)-methyl 3-(4-(N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate

: 1339925-28-8
(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 5 h / 130 °C / Inert atmosphere

2: hydroxylamine / dichloromethane; methanol / 2 h / 0 °C

With hydroxylamine; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1339925-28-8
(E)-3-(4-(N-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2 h / 190 °C

2.1: bromine; acetic acid / 70 °C

3.1: trichlorophosphate / 12 h / Reflux

4.1: methanol / 2 h / 20 °C

5.1: sulfuric acid; nitric acid / 27.5 h / 0 °C

6.1: hydrogenchloride; tin / methanol; water / 50 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 20 °C

7.2: 3 h / Reflux

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; dimethyl sulfoxide / 5 h / 130 °C / Inert atmosphere

9.1: hydroxylamine / methanol; dichloromethane / 2 h / 0 °C

With hydrogenchloride; tin; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydroxylamine; bromine; nitric acid; sodium hydride; sodium hydrogencarbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; mineral oil;