7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

Base Information

Chemical Name:7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin
CAS No.:1550060-81-5
Molecular Formula:C₂₀H₁₉BrO₅
Molecular Weight:419.272
Hs Code.:

Synonyms:7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

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Chemical Property of 7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

Chemical Property:

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Technology Process of 7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

There total 10 articles about 7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 15823-04-8
methyl 3-(4-methoxyphenyl)propionate

: 1550060-75-7
3-bromo-6-(carboxymethyl)-2,4-dimethoxybenzoic acid (4-bromo-3,5-dimethoxyhomophthalic acid)

: 1550060-81-5
7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

Guidance literature:: at 200 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2014.01.009

Reference yield:

: 26050-64-6
methyl 4-bromo-3,5-dimethoxybenzoate

: 1550060-81-5
7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

Guidance literature:: Multi-step reaction with 9 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 8.25 h / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / benzene / 4 h / Inert atmosphere

3: potassium cyanide / ethanol; water / 2 h / Reflux; Inert atmosphere

4: potassium hydroxide / water; 1,4-dioxane; methanol / 48 h / 110 °C / Inert atmosphere

5: sulfuric acid / methanol / 8 h / Reflux; Inert atmosphere

6: trichlorophosphate / N,N-dimethyl-formamide / 55 - 100 °C / Inert atmosphere

7: hydroxylamine hydrochloride; dihydrogen peroxide; hydrogenchloride / acetonitrile / 5 h / 80 °C / Inert atmosphere

8: potassium hydroxide / ethanol; water / 1 h / Reflux; Inert atmosphere

9: 5 h / 200 °C / Inert atmosphere

With hydrogenchloride; potassium cyanide; lithium aluminium tetrahydride; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; phosphorus tribromide; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.tet.2014.01.009

Reference yield:

: 61367-68-8
4-bromo-3,5-dimethoxyphenylacetonitrile

: 1550060-81-5
7-bromo-6,8-dimethoxy-3-(4-methoxyphenethyl)isocoumarin

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / water; 1,4-dioxane; methanol / 48 h / 110 °C / Inert atmosphere

2: sulfuric acid / methanol / 8 h / Reflux; Inert atmosphere

3: trichlorophosphate / N,N-dimethyl-formamide / 55 - 100 °C / Inert atmosphere

4: hydroxylamine hydrochloride; dihydrogen peroxide; hydrogenchloride / acetonitrile / 5 h / 80 °C / Inert atmosphere

5: potassium hydroxide / ethanol; water / 1 h / Reflux; Inert atmosphere

6: 5 h / 200 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2014.01.009