N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

Base Information

Chemical Name:N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide
CAS No.:1094159-83-7
Molecular Formula:C₃₂H₃₆N₆O₄
Molecular Weight:568.676
Hs Code.:

Synonyms:N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

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Technology Process of N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

There total 8 articles about N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1094159-81-5
N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

: 1094159-83-7
N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1002/chem.202004928

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 1094159-83-7
N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 51 h / 0 - 20 °C

3: copper(l) iodide; triphenylphosphine; trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran; triethylamine / 48 h / 20 °C

4: potassium fluoride / methanol / 16 h / 20 °C

With potassium fluoride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; triethylamine; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/om400811z

Reference yield:

: 7065-46-5
3,3-dimethylbutanoic acid chloride

: 1094159-83-7
N,N’-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-ethynylisophthalamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 51 h / 0 - 20 °C

3: copper(l) iodide; triphenylphosphine; trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran; triethylamine / 48 h / 20 °C

4: potassium fluoride / methanol / 16 h / 20 °C

With potassium fluoride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; triethylamine; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/om400811z