N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

Base Information

Chemical Name:N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide
CAS No.:1094159-81-5
Molecular Formula:C₃₅H₄₄N₆O₄Si
Molecular Weight:640.858
Hs Code.:

Synonyms:N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

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Technology Process of N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

There total 7 articles about N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1094159-79-1
N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-5-iodoisophthalamide

: 1066-54-2
trimethylsilylacetylene

: 1094159-81-5
N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2008.08.054

Reference yield:

: 51839-16-8
5-iodoisophthalic acid

: 1094159-81-5
N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 6 h / Inert atmosphere; Reflux

2: triethylamine / tetrahydrofuran / 51 h / 0 - 20 °C

3: copper(l) iodide; triphenylphosphine; trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran; triethylamine / 48 h / 20 °C

With copper(l) iodide; thionyl chloride; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine; In tetrahydrofuran; triethylamine; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/om400811z

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 1094159-81-5
N,N′-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-((trimethylsilyl)ethynyl)isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 51 h / 0 - 20 °C

3: copper(l) iodide; triphenylphosphine; trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran; triethylamine / 48 h / 20 °C

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine; In tetrahydrofuran; triethylamine; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/om400811z