N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Base Information

Chemical Name:N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide
CAS No.:1402164-79-7
Molecular Formula:C₂₃H₂₃Cl₂N₅O₆S
Molecular Weight:568.438
Hs Code.:

Synonyms:N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

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Chemical Property of N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

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Technology Process of N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

There total 6 articles about N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₁Cl₂N₅O₈S

: 1402164-79-7
N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm300931y

Reference yield:

: 164648-75-3
4-(aminomethyl)-2,6-dichloroaniline

: 1402164-79-7
N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: propylamine; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 16 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With propylamine; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm300931y

Reference yield:

: 917388-78-4
tert-butyl N-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

: 1402164-79-7
N-(amino(3,5-dichloro-4-(2-(methylsulfonyl)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: propylamine; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 16 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With propylamine; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm300931y