N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Base Information

Chemical Name:N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide
CAS No.:917388-89-7
Molecular Formula:C₂₇H₂₈BrCl₂N₅O₆
Molecular Weight:669.359
Hs Code.:

N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Synonyms:N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

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Chemical Property of N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

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Technology Process of N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

There total 7 articles about N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1402164-85-5,917475-47-9
N-((4-amino-3,5-dichlorobenzylamino)(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

: 598-21-0
2-Bromoacetyl bromide

: 917388-89-7
N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300931y

Reference yield: 95.0%

: 917475-47-9
(Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate

: 598-21-0
2-Bromoacetyl bromide

: 917388-89-7
C₂₇H₂₈BrCl₂N₅O₆

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2 - 3h;

Reference yield:

: 164648-75-3
4-(aminomethyl)-2,6-dichloroaniline

: 917388-89-7
N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)-(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm300931y