1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne

Base Information

• Chemical Name: 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne
• CAS No.: 938469-59-1
• Molecular Formula: C₁₉H₂₄OSi₂
• Molecular Weight: 324.57
• Mol file: 938469-59-1.mol

Synonyms:1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne

Chemical Property of 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne

There total 3 articles about 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

chlorodimethyl(4-methoxyphenyl)silane (2372-33-0) + (dimethylphenylsilyl)acetylene (17156-64-8) → 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne (938469-59-1)

Guidance literature:

(dimethylphenylsilyl)acetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

chlorodimethyl(4-methoxyphenyl)silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jo070039n

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne (938469-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran

1.2: 79 percent / diethyl ether; tetrahydrofuran / 24 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 97 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; magnesium; In tetrahydrofuran; hexane;

DOI:10.1021/jo070039n

Reference yield:

phenyldimethylsilyl chloride (768-33-2) → 1-[dimethyl(phenyl)silyl]-2-[(4-methoxyphenyl)(dimethyl)silyl]ethyne (938469-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 88 percent / tetrahydrofuran / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 97 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/jo070039n

upstream raw materials:

chlorodimethyl(4-methoxyphenyl)silane

(dimethylphenylsilyl)acetylene

1-bromo-4-methoxy-benzene

phenyldimethylsilyl chloride

Downstream raw materials:

3-[dimethyl(phenyl)silyl]-4-[(4-methoxyphenyl)(dimethyl)silyl]cyclobut-3-ene-1,2-dione