(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Base Information

Chemical Name:(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one
CAS No.:1380402-61-8
Molecular Formula:C₃₀H₂₄ClNO₃S
Molecular Weight:514.044
Hs Code.:

Synonyms:(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Chemical Property of (3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Technology Process of (3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

There total 5 articles about (3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2444-36-2
2'-chloro-benzeneacetic acid

: 358621-92-8
N-(p-tolylsulfonyl)-1,3-diphenyl-2-propen-1-imine

: 1380402-61-8
(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; stereoselective reaction;
DOI:10.1021/acscatal.5b02121

Reference yield:

: C₁₃H₁₅ClO₃

: 143121-73-7
(E)-1,3-diphenyl-1-<<('4-methylphenyl)sulfonyl>imino>-2-propene

: 1380402-61-8
(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201109061

Reference yield:

: 2444-36-2
2'-chloro-benzeneacetic acid

: 1380402-61-8
(3R,4R)-3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 3-(2-chlorophenyl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2: (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1002/anie.201109061