8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

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Chemical Name:8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide
CAS No.:1197331-07-9
Molecular Formula:C₂₉H₃₂N₆O₃
Molecular Weight:512.611
Hs Code.:

Synonyms:8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

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Chemical Property of 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

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Technology Process of 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

There total 14 articles about 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197332-94-7
8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

: 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride

: 1197331-07-9
8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Guidance literature:: 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester; 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride; With trimethylaluminum; In toluene; at 20 ℃; for 4h; Reflux;

With water; In ethyl acetate; toluene;

Reference yield:

: 15155-41-6
4,7-dibromobenzo[c][1,2,5]thiadiazole

: 1197331-07-9
8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere

2.1: ethanol; water / 3 h / Reflux

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

4.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

5.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

5.2: pH 5

6.1: sulfuric acid / 7 h / Reflux

7.1: trimethylaluminum / toluene / 4 h / 20 °C / Reflux

With sodium tetrahydroborate; sulfuric acid; trimethylaluminum; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; toluene;

Reference yield:

: 273-13-2,22706-22-5
benzo[1,2,5]thiadiazole

: 1197331-07-9
8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen bromide; bromine / water / 4 h / Reflux

2.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere

3.1: ethanol; water / 3 h / Reflux

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

5.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

6.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

6.2: pH 5

7.1: sulfuric acid / 7 h / Reflux

8.1: trimethylaluminum / toluene / 4 h / 20 °C / Reflux

With sodium tetrahydroborate; sulfuric acid; hydrogen bromide; bromine; trimethylaluminum; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; toluene;