8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Base Information

• Chemical Name: 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide
• CAS No.: 1197331-07-9
• Molecular Formula: C₂₉H₃₂N₆O₃
• Molecular Weight: 512.611
• Mol file: 1197331-07-9.mol

Synonyms:8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Chemical Property of 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

There total 14 articles about 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (1197332-94-7) + 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride → 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide (1197331-07-9)

Guidance literature:

8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester; 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride; With trimethylaluminum; In toluene; at 20 ℃; for 4h; Reflux;

With water; In ethyl acetate; toluene;

Reference yield:

4,7-dibromobenzo[c][1,2,5]thiadiazole (15155-41-6) → 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide (1197331-07-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere

2.1: ethanol; water / 3 h / Reflux

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

4.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

5.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

5.2: pH 5

6.1: sulfuric acid / 7 h / Reflux

7.1: trimethylaluminum / toluene / 4 h / 20 °C / Reflux

With sodium tetrahydroborate; sulfuric acid; trimethylaluminum; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; toluene;

Reference yield:

benzo[1,2,5]thiadiazole (273-13-2,22706-22-5) → 8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide (1197331-07-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogen bromide; bromine / water / 4 h / Reflux

2.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere

3.1: ethanol; water / 3 h / Reflux

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

5.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

6.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

6.2: pH 5

7.1: sulfuric acid / 7 h / Reflux

8.1: trimethylaluminum / toluene / 4 h / 20 °C / Reflux

With sodium tetrahydroborate; sulfuric acid; hydrogen bromide; bromine; trimethylaluminum; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; toluene;

upstream raw materials:

8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

6-((tert-butoxycarbonyl)amino)nicotinic acid ethyl ester

benzo[1,2,5]thiadiazole

ethyl-6-amino-nicotinate