3-Pyridinecarboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester
• CAS No.: 169280-82-4
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.297
• Hs Code.: 2933399990
• Mol file: 169280-82-4.mol

Synonyms:6-BOC-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID;ethyl 6-(tert-butoxycarbonylamino)nicotinate;6-tertbutoxycarbonylamino nicotinic acid ethyl ester;ethyl 6-(tert-butyloxycarbonylamino)nicotinate;6-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[2.3-c]pyridine-2-carboxylic acid;

Chemical Property of 3-Pyridinecarboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester

Chemical Property:

• Boiling Point: 336.7±27.0 °C(Predicted)
• PKA: 12.02±0.70(Predicted)
• PSA: 81.01000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 2.61890

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl6-{[(tert-butoxy)carbonyl]-amino}pyridine-3-carboxylate >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl-6-amino-nicotinate (39658-41-8) + di-tert-butyl dicarbonate (24424-99-5) → 6-((tert-butoxycarbonyl)amino)nicotinic acid ethyl ester (169280-82-4)

Guidance literature:

With dmap; In acetone; tert-butyl alcohol; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2003.12.039

Reference yield:

ethyl-6-amino-nicotinate (39658-41-8) + carbamic Acid (463-77-4) → 6-((tert-butoxycarbonyl)amino)nicotinic acid ethyl ester (169280-82-4)

Guidance literature:

With triethylamine; In ethyl acetate; toluene;

Reference yield:

ethyl-6-amino-nicotinate (39658-41-8) → 6-((tert-butoxycarbonyl)amino)nicotinic acid ethyl ester (169280-82-4)

Guidance literature:

With triethylamine; In ethyl acetate; toluene;

upstream raw materials:

ethyl-6-amino-nicotinate

di-tert-butyl dicarbonate

6-aminonicotinic acid

carbamic Acid

Downstream raw materials:

8-(3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

6-[(tert-butoxycarbonyl)amino]nicotinic acid

3-(2,6-difluorophenyl)-1-ethyl-7-((5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

7-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]isoquinolin-3-amine