3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

Base Information

Chemical Name:3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine
CAS No.:1346818-53-8
Molecular Formula:C₂₀H₂₆BFN₂O₄
Molecular Weight:388.247
Hs Code.:

Synonyms:3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

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Chemical Property of 3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

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Technology Process of 3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

There total 1 articles about 3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1346818-34-5
5-bromo-3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-2-ylamine

: 73183-34-3
bis(pinacol)diborane

: 1346818-53-8
3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield: 6.3%

: 1346818-58-3
5-iodo-4-methyl-1-vinyl-1H[1,2,3]triazole

: 1346818-53-8
3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

: 1346814-42-3
3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4-methyl-1-vinyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 110 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1346818-53-8
3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

: 1346814-84-3
2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 72 h / 60 °C

With sodium hydrogencarbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide;