2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

Base Information

Chemical Name:2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol
CAS No.:1346814-84-3
Molecular Formula:C₂₁H₂₂FN₃O₄
Molecular Weight:399.422
Hs Code.:

Synonyms:2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

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Chemical Property of 2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

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Technology Process of 2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

There total 3 articles about 2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346819-94-0
2'-chloro-5-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-[3,3'-bipyridin]-6-amine

: 107-21-1
ethylene glycol

: 1346814-84-3
2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 60 ℃; for 72h;

Reference yield:

: 1346818-53-8
3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine

: 1346814-84-3
2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 72 h / 60 °C

With sodium hydrogencarbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 1346818-34-5
5-bromo-3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-2-ylamine

: 1346814-84-3
2-{6'-amino-5'-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-(3,3'-bipyridinyl)-2-yloxy}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3: potassium hydroxide / dimethyl sulfoxide / 72 h / 60 °C

With potassium acetate; sodium hydrogencarbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide;