O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

Base Information

Chemical Name:O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine
CAS No.:1335111-39-1
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

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Chemical Property of O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

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Technology Process of O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

There total 5 articles about O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1335111-30-2
O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)hydroxylamine

: 1335111-39-1
O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

: 123-11-5
4-methoxy-benzaldehyde

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 70 ℃; for 96h; Inert atmosphere;
DOI:10.1021/jm200794r

Reference yield:

: 1335111-22-2
N-Boc-O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)hydroxylamine

: 1335111-39-1
O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

: 123-11-5
4-methoxy-benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 96 h / 70 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; toluene; 2: Buchwald-Hartwig amination;
DOI:10.1021/jm200794r

Reference yield:

: 2014-61-1
N-(4-methoxybenzyloxy)phthalimide

: 1335111-39-1
O-(4-methoxybenzyl)-N-(4-(trifluoromethoxy)benzyl)-N-(pyridin-2-yl)hydroxylamine

: 123-11-5
4-methoxy-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / methanol; N,N-dimethyl-formamide / 0.17 h / 60 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 22 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 96 h / 70 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; trifluoroacetic acid; sodium t-butanolate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: Buchwald-Hartwig amination;
DOI:10.1021/jm200794r