2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Name:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine
CAS No.:1332875-00-9
Molecular Formula:C₂₁H₁₈Cl₂F₃N₅
Molecular Weight:468.309
Hs Code.:

Synonyms:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Property of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Technology Process of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

There total 12 articles about 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1332874-98-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-amino-4-chloro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

: 1332875-00-9
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-amino-4-chloro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide; (1S)-10-camphorsulfonic acid; In 1,4-dioxane; at 100 ℃; for 3h;

With sodium hydrogencarbonate; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 116632-24-7
2-amino-4,6-dichloropyridine

: 1332875-00-9
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere

2.1: sulfuric acid / 1 h / 0 °C

2.2: 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

4.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

5.1: ammonium chloride; iron / ethanol; water / 5 h / 60 °C

6.1: (1S)-10-camphorsulfonic acid / 1,4-dioxane / 3 h / 100 °C

With sulfuric acid; iron; sodium hydride; ammonium chloride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; (1S)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; mineral oil; 1.1: Suzuki Coupling;

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1332875-00-9
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-7-chloro-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere

2.1: sulfuric acid / 1 h / 0 °C

2.2: 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

4.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

5.1: ammonium chloride; iron / ethanol; water / 5 h / 60 °C

6.1: (1S)-10-camphorsulfonic acid / 1,4-dioxane / 3 h / 100 °C

With sulfuric acid; iron; sodium hydride; ammonium chloride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; (1S)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; mineral oil; 1.1: Suzuki Coupling;