(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

Base Information

Chemical Name:(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide
CAS No.:911048-67-4
Molecular Formula:C₂₆H₃₅N₃O₃Si
Molecular Weight:465.668
Hs Code.:

Synonyms:(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

There total 6 articles about (8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(benzyloxy)-N,N,2-trimethyl-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazole-6-carboxamide

: 911048-67-4
(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 3750.38 Torr

2.1: dichloromethane / 3 h / 20 °C

2.2: 3 h / Heating / reflux

3.1: hydrogen / RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN] / water; isopropyl alcohol; tert-butyl alcohol / 20 h / 65 °C / 60006 Torr

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN]; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 774582-78-4
4-hydroxy-N,N,2-trimethyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole-6-carboxamide

: 911048-67-4
(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 3 h / 20 °C

1.2: 3 h / Heating / reflux

2.1: hydrogen / RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN] / water; isopropyl alcohol; tert-butyl alcohol / 20 h / 65 °C / 60006 Torr

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN]; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 774582-60-4
6-bromo-2-methyl-4-[(phenylmethyl)oxy]-1H-benzimidazole

: 911048-67-4
(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

2.1: palladium diacetate; triphenylphosphine / tetrahydrofuran / 60 h / 120 °C / 4500.45 Torr

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 3750.38 Torr

4.1: dichloromethane / 3 h / 20 °C

4.2: 3 h / Heating / reflux

5.1: hydrogen / RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN] / water; isopropyl alcohol; tert-butyl alcohol / 20 h / 65 °C / 60006 Torr

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; palladium diacetate; RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN]; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;