(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

Base Information

Chemical Name:(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt
CAS No.:911048-69-6
Molecular Formula:C₂H₂O₄*C₂₀H₂₁N₃O₂
Molecular Weight:425.441
Hs Code.:

Synonyms:(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

There total 8 articles about (8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 911048-67-4
(8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

: 144-62-7,97993-78-7
oxalic acid

: 911048-69-6
(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

Guidance literature:: (8S)-2-methyl-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide; With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; for 20h;

oxalic acid; In acetone;

Reference yield:

: 911048-68-5
(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide

: 144-62-7,97993-78-7
oxalic acid

: 911048-69-6
(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

Guidance literature:: In acetone; at 20 ℃; for 18h;

Reference yield:

: 774582-78-4
4-hydroxy-N,N,2-trimethyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole-6-carboxamide

: 911048-69-6
(8S)-2-methyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid dimethylamide oxalyc acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 3 h / 20 °C

1.2: 3 h / Heating / reflux

2.1: hydrogen / RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN] / water; isopropyl alcohol; tert-butyl alcohol / 20 h / 65 °C / 60006 Torr

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 20 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; hydrogen; triphenylphosphine; RuCI₂[(S)-Xyl-P-Phos][(S)-DAIPEN]; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; tert-butyl alcohol;