5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine
• CAS No.: 1346447-76-4
• Molecular Formula: C₂₀H₂₀ClN₅O₄S
• Molecular Weight: 461.929

Synonyms:5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine

Chemical Property of 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine

There total 5 articles about 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(3-nitrobenzyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.1%

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine (761440-16-8) + 3-nitrobenzylamine (7409-18-9) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(3-nitrobenzyl)pyrimidine-2,4-diamine (1346447-76-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(3-nitrobenzyl)pyrimidine-2,4-diamine (1346447-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

2-(isopropyl sulfanyl)nitrobenzene (70415-85-9) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(3-nitrobenzyl)pyrimidine-2,4-diamine (1346447-76-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine

3-nitrobenzylamine

ortho-nitrofluorobenzene

2-(isopropyl sulfanyl)nitrobenzene

Downstream raw materials:

N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

N-(3-(((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)methyl)phenyl)acrylamide

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