4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Base Information

• Chemical Name: 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine
• CAS No.: 198551-04-1
• Molecular Formula: C₂₄H₂₆N₄O₂
• Molecular Weight: 402.496
• Mol file: 198551-04-1.mol

Synonyms:4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Chemical Property of 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

There total 4 articles about 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

guanidine hydrochloride (50-01-1) + 4-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione (198554-58-4) → 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine (198551-04-1)

Guidance literature:

With pyridine; potassium carbonate; at 110 ℃;

DOI:10.1016/S0960-894X(00)00227-4

Reference yield:

1-benzoylisonipecotic acid (5274-99-7) → 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine (198551-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃ / Heating

2: LDA / tetrahydrofuran / -70 °C

3: 45 percent / K₂CO₃; pyridine / 110 °C

With pyridine; thionyl chloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; chloroform; 1: Chlorination / 2: Condensation / 3: Cyclization;

DOI:10.1016/S0960-894X(00)00227-4

Reference yield:

1-benzoyl-4-piperidinecarbonyl chloride (115755-50-5) → 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine (198551-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / -70 °C

2: 45 percent / K₂CO₃; pyridine / 110 °C

With pyridine; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1: Condensation / 2: Cyclization;

DOI:10.1016/S0960-894X(00)00227-4

upstream raw materials:

guanidine hydrochloride

4-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

1-benzoylisonipecotic acid

1-benzoyl-4-piperidinecarbonyl chloride

Downstream raw materials:

4-[1-(1,3-benzodioxol-5-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine