198554-58-4Relevant academic research and scientific papers
Novel piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation
Fujiwara, Norio,Nakajima, Takashi,Ueda, Yutaka,Fujita, Hitoshi,Kawakami, Hajime
experimental part, p. 9804 - 9816 (2009/04/06)
Piperidinylpyrimidine derivatives, previously prepared as inhibitors of TNF-α production, were evaluated for their inhibitory activity against HIV-1 LTR activation. Some of these derivatives inhibited activation of HIV-1 LTR-directed CAT gene expression i
Synthesis and bioactivities of novel piperidylpyrimidine derivatives: Inhibitors of tumor necrosis factor-alpha production
Fujiwara, Norio,Fujita, Hitoshi,Iwai, Kiyotaka,Kurimoto, Ayumu,Murata, Shinobu,Kawakami, Hajime
, p. 1317 - 1320 (2007/10/03)
New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-α production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure-activity relationships of these compounds are described. (C) 2000 Elsevier Science Ltd. All rights reserved.
