1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline

Base Information

• Chemical Name: 1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline
• CAS No.: 84500-68-5
• Molecular Formula: C18H20N2
• NSC Number: 281678
• DSSTox Substance ID: DTXSID50314240
• Nikkaji Number: J1.959.836E
• Mol file: 84500-68-5.mol

Synonyms:84500-68-5;1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline;NSC 281678;NSC281678;SCHEMBL16799768;DTXSID50314240;BCP30040;BCP30041;NSC-281678;1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline pound>>1-(1,2,3,4-tetrahydroisoquinolin-1-yl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 264.162648646
• Heavy Atom Count: 20
• Complexity: 297

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC(C2=CC=CC=C21)C3C4=CC=CC=C4CCN3

Technology Process of 1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline

There total 8 articles about 1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4-dihydroisoquinoline (3230-65-7) → 1,1'-bi(1,2,3,4-dihydroisoquinolyl) (84500-68-5,634180-45-3)

Guidance literature:

With chloro-trimethyl-silane; ethylene dibromide; zinc; In acetonitrile; at 35 - 40 ℃; for 12h;

DOI:10.1039/b306159k

Reference yield: 71.0%

3,3′,4,4′-tetrahydro-1,1′-biisoquinoline (34786-39-5) → 1,1'-bi(1,2,3,4-dihydroisoquinolyl) (84500-68-5,634180-45-3)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃;

DOI:10.1055/s-0033-1341125

Reference yield:

3,4-dihydroisoquinoline (3230-65-7) → 1,1'-bi(1,2,3,4-dihydroisoquinolyl) (84500-68-5,634180-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / HCl / H₂O

2: AlH₃ / diethyl ether

With aluminium hydride; hydrogenchloride; In diethyl ether; water;

DOI:10.1021/jm00358a010

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

3,4-dihydroisoquinoline

N-(2-phenylethyl)formamide

phenethylamine