Formamide, N-(2-phenylethyl)-

Base Information

• Chemical Name: Formamide, N-(2-phenylethyl)-
• CAS No.: 23069-99-0
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2924299090
• Mol file: 23069-99-0.mol

Synonyms:Formamide,N-phenethyl- (6CI,7CI,8CI); (2-Phenylethyl)formamide;N-(2-Phenylethyl)formamide; N-(b-Phenylethyl)formamide; N-Formyl-N-(2-phenylethyl)amine;N-Formylphenethylamine; N-Phenethylformamide; N-b-Phenethylformamide; NSC 18966

Chemical Property of Formamide, N-(2-phenylethyl)-

Chemical Property:

• Vapor Pressure: 0.000117mmHg at 25°C
• Refractive Index: n20/D1.546
• Boiling Point: 335.8°Cat760mmHg
• PKA: 16.04±0.23(Predicted)
• Flash Point: 195.6°C
• PSA: 29.10000
• Density: 1.029g/cm³
• LogP: 2.00190
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(Phenethyl)formamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reactant for:Preparation of allenamides by alkylation with propargyl bromide and isomerizationUgi 3CC reaction

Technology Process of Formamide, N-(2-phenylethyl)-

There total 36 articles about Formamide, N-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formic acid (64-18-6) + phenethylamine (64-04-0) → N-(2-phenylethyl)formamide (23069-99-0)

Guidance literature:

formic acid; With acetic acid; at 25 ℃; for 1h;

phenethylamine; at 0 - 25 ℃;

DOI:10.1021/acs.chemrestox.9b00504

Reference yield: 99.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + phenethylamine (64-04-0) → N-(2-phenylethyl)formamide (23069-99-0)

Guidance literature:

With chitosan; In neat (no solvent); at 80 ℃; for 36h; Sealed tube;

DOI:10.1039/c4gc01402b

Reference yield: 99.0%

phenethylamine (64-04-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-(2-phenylethyl)formamide (23069-99-0)

Guidance literature:

With tris(2,2,2-trifluoroethyl) borate; In acetonitrile; at 80 ℃; for 5h;

DOI:10.1021/jo400509n

upstream raw materials:

phenylacetonitrile

formamide

formic acid ethyl ester

chloral

Downstream raw materials:

(S)-3-methyl-1-phenethylpyrrolidin-2-one

N-(2-Phenylethyl)-(4-phenyl)aniline

N-(2-Phenylethyl)-2,3-dihydro-1H-isoindol-1-on

5-[[4-[2-[benzyl[(2R)-2-[[tert-butyl-(dimethyl)silyl]oxy]-2-(3-chlorophenyl)ethyl]amino]ethyl]-phenyl]sulfonyl]-2-(benzyloxy)benzoic acid

Refernces

• 1、 Elliott, Mark C.,Williams, Eve. "Synthesis and reactions of partially reduced biisoquinolines". . p. 3038 - 3047. Retrieved 2003.
• 2、 Weinhagen. "". . p. 273. Retrieved 1917.
• 3、 Xu, Shuheng,Cui, Sunliang. "SuFExable Isocyanides for Ugi Reaction: Synthesis of Sulfonyl Fluoro Peptides". supporting information. p. 5197 - 5202. Retrieved 2021/07/20.
• 4、 Zhang, Yanmeng,Zhang, He,Gao, Ke. "Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2". supporting information. p. 8282 - 8286. Retrieved 2021/10/25.