(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

Base Information

Chemical Name:(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide
CAS No.:554448-72-5
Molecular Formula:C₃₁H₃₁F₂N₃O₄
Molecular Weight:547.602
Hs Code.:

Synonyms:(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

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Chemical Property of (2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

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Technology Process of (2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

There total 6 articles about (2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{(benzyloxycarbonylamino-indan-2-yl-acetyl)-[(2-benzyloxy-phenylcarbamoyl)-(2,4-difluoro-phenyl)-methyl]-amino}-4-methyl-pentanoic acid methyl ester

: 554448-72-5
(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; for 2h;
DOI:10.1021/jm060073e

Reference yield:

: 2-[(2,4-difluoro-benzylidene)-amino]-4-methyl-pentanoic acid methyl ester

: 554448-72-5
(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: 2.0 g / H₂; AcOH / Pd/C / ethyl acetate / 2 h

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; ethyl acetate; 1: Ugi reaction;
DOI:10.1021/jm060073e

Reference yield:

: 554448-74-7
(2R)-2,3-dihydro-1H-inden-2-yl({[(phenylmethyl)oxy]carbonyl}amino)ethanoic acid

: 554448-72-5
(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: 2.0 g / H₂; AcOH / Pd/C / ethyl acetate / 2 h

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; ethyl acetate; 1: Ugi reaction;
DOI:10.1021/jm060073e